HNF - Helmholtz Nano Facility

The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription.

The transcription factors that act in hepatocyte-specific gene expression include proteins that are present mainly in liver cells (HNF-1/LFB1, C/EBP, HNF-3, HNF-4) (HNF, hepatocyte nuclear factor; C/EBP, rat enhancer binding protein) and proteins that are widely distributed (AP-1, NF-1, NF-Y/ACF). We show here that the genes encoding each of these liver-enriched factors exhibit different patter...

Contributions to the Theory of Thermostated Systems II: Least Dissipation of Helmholtz Free Energy in Nano-Biology

In this paper, we develop further the theory of thermostated systems along the lines of our earlier paper ([1] Fox). Two results are highlighted: 1) in the Markov limit of the contracted description, a least dissipation of Helmholtz free energy principle is established; and 2) a detailed account of the appropriateness of this principle for nanobiology, including the evolution of life, is presen...

Varieties of Helmholtz Machine

The Helmholtz machine is a new unsupervised learning architecture that uses top-down connections to build probability density models of input and bottom-up connections to build inverses to those models. The wake-sleep learning algorithm for the machine involves just the purely local delta rule. This paper suggests a number of different varieties of Helmholtz machines, each with its own strength...

Preconditioning Helmholtz linear systems

Linear systems which originate from the simulation of wave propagation phenomena can be very difficult to solve by iterative methods. These systems are typically complex valued and they tend to be highly indefinite, which renders the standard ILU-based preconditioners ineffective. This paper presents a study of ways to enhance standard preconditioners by altering the diagonal by imaginary shift...

Kelvin-Helmholtz Instabilities